New Device for Inhibiting Arterial Plaque Growth

ثبت نشده
چکیده

When partial or complete closure of a coronary artery occurs, angioplasty is commonly performed to reopen the artery. However, the frustration of laser and balloon angioplasty is that in many cases the plaque quickly accumulates to reclose the artery and this phenomenon is called restenosis. A device has been developed to deliver externally generated ionizing dose of pulsed x-ray irradiation to the arterial wall to prevent restenosis. This device can be also used for other therapeutic applications such as irradiation of tumors with minimal damage to surrounding healthy tissues.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Myxomavirus Anti-Inflammatory Chemokine Binding Protein Reduces the Increased Plaque Growth Induced by Chronic Porphyromonas gingivalis Oral Infection after Balloon Angioplasty Aortic Injury in Mice

Thrombotic occlusion of inflammatory plaque in coronary arteries causes myocardial infarction. Treatment with emergent balloon angioplasty (BA) and stent implant improves survival, but restenosis (regrowth) can occur. Periodontal bacteremia is closely associated with inflammation and native arterial atherosclerosis, with potential to increase restenosis. Two virus-derived anti-inflammatory prot...

متن کامل

Local inhibition of tissue factor reduces the thrombogenicity of disrupted human atherosclerotic plaques: effects of tissue factor pathway inhibitor on plaque thrombogenicity under flow conditions.

BACKGROUND Plaque disruption and subsequent thrombus formation lead to acute coronary syndromes and progression of atherosclerotic disease. Tissue factor (TF) appears to mediate plaque thrombogenicity. Tissue factor pathway inhibitor (TFPI) is the major physiological inhibitor of TF. This study analyzes the role of TF on thrombogenicity of disrupted human atherosclerotic plaques and the therape...

متن کامل

Arterial Wall Mechanics and Clinical Implications after Coronary Stenting: Comparisons of Three Stent Designs

The goal of this work is to quantitatively assess the relationship between the reported restenosis rates and stent induced arterial stress or strain parameters through finite element method. The impact of three stent designs (Palmaz–Schatz stent, Express stent, and Multilink Vision stent) on the arterial stress distributions were characterized. The influences of initial stent deployment locatio...

متن کامل

The viral anti-inflammatory chemokine-binding protein M-T7 reduces intimal hyperplasia after vascular injury.

Chemokines and IFN-gamma function as central regulators of inflammatory responses to vascular injury. Both classes of cytokines are upregulated during restenosis, a response to vascular injury that leads to recurrent atherosclerotic plaque growth, but the relative impact of each class of cytokines remains undetermined. M-T7 is a secreted myxoma viral immunomodulatory glycoprotein that functions...

متن کامل

Modeling of stent implantation in a human stenotic artery 0850v1.docx Modeling of stent implantation in a human stenotic artery

The aim of this work is to introduce a methodology to study the stent expansion and the subsequent deformation of the arterial wall towards the outside direction in order arterial lesion to be rehabilitated and blood flow to be restored. More specifically, a coronary artery and the plaque are reconstructed using intravascular ultrasound and biplane angiography. The finite element method is used...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006